Nishimura Style
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Publications

Yasumitsu Nishimura, Ph. D.
Assistant Professor / Lecturer
Dept of Hygiene, Kawasaki Medical School

Publications

  Anti-tumor immunity, asbestos and mesothelioma

  Keyward: NK cell, asbestos, mesothelioma, cytotoxicity, NKG2D, NKp46
NK and asbestos
   The present primary study, in Kawasaki Medical School, is to investigate effect of exposure to asbestos on effector cells, NK cells and cytotoxic T-lymphocytes (CTLs). In particular, the several effects on NK cells have been already found out, to date. In addition, I also have provided more than a little contribution to the studies about effect of asbestos on regulatory T-cells (Treg) and others, organized by Prof. T. Otsuki, my boss. Most of the publication are shown bellow. The others can be checked from  here

  1. Nishimura Y, Maeda M, Kumagai N, Hayashi H, Miura Y, Otsuki T. Decrease in phosphorylation of ERK following decreased expression of NK-cell activating receptors in human NK cell line exposed to asbestos.Int J Immunopathol Pharmacol 2009 Oct-Dec;22(4):879-88.
  2. Nishimura Y, Miura Y, Maeda M, KUmagai N, Murakami S, Hayashi H, Fukuoka K, Nakano T, Otsuki T. Impairment in cytotoxicity and expression of NK-cell activating receptors on human NK cells following exposure to asbestos fibers. Int J Immunopathol Pharmacol 2009 Jul-Sep;22(3):579-90.
  3. Murakami S, Nishimura Y, Maeda M, Kumagai N, Hayashi H, Chen Y, Kusaka K, Kishimoto T, Otsuki t. Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. Environ Health Prev Med 14(4): 216-222, 2009
  4. Otsuki T，Maeda M, Miura Y, Hayashi H, Murakami S, Kumagai N, Nishimura Y. Immunological effects of Asbestos. In Asbestos: Risks, Environment and Impact. Eds: Antonio Soto and Gael Salazar, ISBN 978-1-60692-053-4,   © 2009 Nova Science Publishers, Inc. 2009
  5. Miura Y, Nishimura Y, Maeda M, Murakami S, Hayashi H, Fukuoka K, Kishimoto T, Nakano T, Otsuki T. Immunological alterations found in mesothelioma patients and their experimental evidences.Environ Health Prev Med 13: 55-59, 2008
  6. Maeda M, Miura Y, Nishimura Y, Murakami S, Hayashi H, Kumagai N, Hatayama T, Katoh M, Miyahara N, Yamamoto S, Fukuoka K, KishimotoT, Nakano T, Otsuki T. Immunological changes in mesothelioma patients and their experimental detection. Clin Med: Circ, Resp Pulm Med 2: 11-17, 2008
  7. Otsuki T, Maeda M, Murakami S, Hayashi H, Miura Y, Kusaka M, Nakano T, Fukuoka K, Kishimoto T, Hyodoh F, Ueki A, Nishimura Y.Immunological effects of silica and asbestos. Cell Mol Immnol 4(4):261-8, 2007
  8. Nishimura Y, Miura Y, Maeda M, Hayashi H, Dong M, Katsuyama H, Tomita M, Hyodoh F, Uesaka A, Kuribayashi K, Fukuoka K, Nakano T, Kishimoto T. Expression of the T cell receptor Vβ repertoire in a human T cell resistant to asbestos-induced apoptosis and peripheral blood T cells from patients with silica and asbestos-related diseases. Int J Immunopathol Pharmacol 19(4): 795-805, 2006
  9. Otsuki T, Miura Y, Nishimura Y, Hyodoh F, Takata A, Kusaka M, Katsuyama H, Tomita M, Ueki A, Kishimoto T. Alterations of Fas and Fas-related molecules in patients with silicosis. [Review artic]e] Exp Biol Med 231(5): 522-33, 2006
  10. Miura Y, Nishimura Y, Katsuyama H, Maeda M, Hayashi H, Dong M, Hyodoh F, Tomita M, Mastuo Y, Uesaka A, Kuribayashi K, Nakano T, Kishimoto T, Otsuki T, Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells. Apoptosis 11(10): 1825-35, 2006
  11. Wu P, Miura Y, Hyodoh F, Nishimura Y, Hatayama T, Hatada S, Sakaguchi H, Kusaka M, Katsuyama H, Tomita M, Otsuki T. Reduced function of CD4+25+ regulatory T cell fraction in silicosis patients.Int J Immunopathol Pharmacol 19(2): 357-68, 2006
  12. Otsuki T, Miura Y, Maeda M, Hayashi H, Dong M, Nishimura Y, Tomita M, Katsuyama H. Asbestos-related carcinogenesis and immunological effects (Focus lecture 1). Biomed Res Trace Elements 17(2): 99-103, 2006


  Alveolra macrophages, asbestos and  lung fibrosis

  Keyward: alveolar macrophage, asbestos, TGF-beta, apoptosis, bcl-xL

   These are the publications of studies about functional alteration of alveolar macrophages upon exposure to asbestos, investigated with Prof.H. Iguchi during the period in Dept of Environmental and Preventive Medicine, Hyogo College of Medicine. In particular, we demonstrated that alveolar macrophages have a potential to develop fibrogenic feature with high production of TGF-beta and long survival, without help from other types of cells in lungs and apoptotic cell-death following inflamation.

AM and asbestos
  1. Nishimura Y, Nishiike-Wada T, Wada Y, Miura Y, Otsuki T, Iguchi H. Long-lasting production of TGF-beta1 by alveolar macrophages exposed to low doses of asbestos without apoptosis. Int J Immunopathol Pharmacol 20(4): 661-667, 2007
  2. Nishiike T, Nishimura Y, Wada Y, Iguchi H, Production of nitric oxide elevates nitrosothiol formation resulting in decreased glutathione in macrophages exposed to asbestos or asbestos substitutes.Arch Toxicol, 79: 83-89, 2005
  3. Nishimura Y, Nishiike T, Wada Y, Iguchi H, Functional Alteration of the Alveolar Macrophages Exposed to Asbestos Fiber: the Production of TGF-b, Apoptosis and the Generation of Multinucleated Giant Cells, Annals of The Global Asbestos Congress, GAC 2004, Furuya S & Allen D (eds) Kazan, McClain, Abrams, Fernandes, Lyons & Farrise, CA, 2005
  4. Nishiike T, Nishimura Y, Wada Y, Iguchi H, Exposure of Macrophages to Asbestos or Man-Made Mineral Fibers Causes Oxidative Stress through a Change in the Levels of S-nitrosothiol and Cellular Glutathione, Annals of The Global Asbestos Congress, GAC 2004, Furuya S & Allen D (eds) Kazan, McClain, Abrams, Fernandes, Lyons & Farrise, Ca, 2005

  Accelerated senescence and  T helper cells

  Keyward: immunosenescence, SAM, Th cell, proliferation, IL-2, apoptosis,


SAM mice
10 month old male, SAMP1 (top) and SAMR1 (bottom)
 
   These are the publications of studies about immune senescence and accelerated senescence using senesence-accelerated mice (SAM) strains, investigated with Dr. M. Hosokawa and Prof. T. Hosokawa during the period in Kyoto University. In particular, we demonstrated that insufficient production of IL-2 caused impaired proliferation and early apoptosis of splenic CD4+ T cells in SAMP1 mice, which hade been reported to exhibit a marked decrease in antibody response to T-dependent antigen even at 2 months old of age, by T. Hosokawa and et al.

SAMP1 and IL-2

  1. Nishimura Y, Hosokawa T, Hosono M, Baba M, Iguchi H, Hosokawa M, The stability of interleukin-2 mRNA transcribed in splenic CD4+ T cells from SAMP1 mice, Int Congr Ser, 1260, 221-225, 2004
  2. Nishimura Y, Hosokawa T, Hosono M, Baba M and Hosokawa M, Insufficient interleukin-2 production from splenic CD4+ T cells causes impaired cell proliferation and early apoptosis in SAMP1, a strain of senescence-accelerated mouse. Immunology, 107(2): 190-198, 2002
  3. Zhu B, Ueno M, Matsushita M, Fujisawa H, Seriu N, Nishikawa T, Nishimura Y, Hosokawa M., Effects of aging and blood pressure on the structure of the thoracic aorta in SAM mice: a model of age-associated degenerative vascular changes, Exp Gerontol, 36: 111-124, 2001
  4. Fujisawa H, Nishikawa T, Zhu B, Nishimura Y, Shimizu M, Kimoto M, Higuchi K, Hosokawa M., Aminoguanidine supplementation delays the onset of senescence in vitro in dermal fibroblast-like cells from senescence-accelerated mice, J Gerontol, 54: B276-82, 1999
  5. Nishikawa T, Takahashi J. A, Fujibayashi Y, Fujisawa H, Zhu B, Nishimura Y, Ohnishi K, Higuchi K, Hashimoto H, Hosokawa M, An early stage mechanism of the age-associated mitochondrial dysfunction in the brain of SAMP8 mice; an age-associated neurodegeneration animal model, Neurosci Lett, 254: 69-72, 1998


Publications

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