1) Analysis of the mechanism in patients with
We have already conducted the analysis of more than 1,000 cases with hemolytic
anemia of unknown mechanism, and provided the analytical results to many
hospitals in Japan.
2) Pathophysiological clarification and
treatment of autoimmune hematological disease.
Autoimmune hematological diseases are autoimmune hemolytic anemia, idiopathic
thrombocytopenic purpura, aplastic anemia and low-grade myelodysplastic
syndrome. We have applied immune therapy to these diseases.
3) Pathophysiological elucidation and
treatment of hematological malignancies.
We have provided individual treatments to patients with hematological malignancies
such as leukemia, myeloma and malignant lymphoma. We collaborate not only
with the Pathology and Radiology Department, but also with many other departments.
We think a combined modality therapy is very important for patients with
4) Hematopoietic stem cell
We performed 302 cases of hematopoietic stem cell transplantation in the
last ten years, comprising 101 auto PBSCT, 140 CBT, 36 allo- BMT and 25
5) Clinical service as the core model hospital for AIDS.
We provide clinical services for HIV/AIDS patients and education to
medical doctors and paramedical staff who may have contact with HIV/AIDS
patients as the core model hospital for AIDS in Okayama Prefecture.
1) Student instruction
i) Introduction to internal medicine as clinical medicine.
It is important to create a good clinician before clinical training is
started, and to acquire self-knowledge and a fundamental ability as a medical
doctor to the highest degree.
ii) C1assified block lectures on hematology.
The lectures are carried out during the first term of the third year.
Hematological disorders may almost be divided into six groups: 1) Red cell
disease, 2) Granulocyte disease, 3) Lymphocyte disease which causes swelling in
the lymphoid tissue, 4) Abnormal coagulation disorders, 5) Hematopathology, and
6)Pediatric hematology. The lectures deal with these disease groups, while
contrasting normal states with those that are abnormal.
iii) Clinical practice training in hematological disease.
During the fifth year, students study clinical cases in small groups of
five persons or less. Clinical physicians guide each group carefully.
iv) Summary of Hematology.
During the sixth year, students receive hematology lectures to organize
their knowledge and to approach disorders from the standpoint of symptoms.
2) Postgraduate education program.
Our hospital has a training system in which residents (called junior
residents) study in all clinical sections for two years. In this program, they
are required not only to learn the basic rules for physicians, but also to gain
the knowledge necessary to become a specialist in internal medicine who will
become a fellow of the Japanese Society of Internal Medicine. As senior
residents, they then undergo training to become a specialist in the hematological
section to become a fellow of the Japanese Society of Hematology. After this
training, they take the graduate course and study how to solve clinical
problems from various points of view．
Main Areas and Themes of Research
1) Research on red blood cells.
Since the establishment of our department, we have carried out research
on red blood cells as a main theme. Some staff members of our division who have
proceeded to a doctor’s degree through research on this theme continue research
on red blood cell membrane disorders. In this research, we have
collaborated with the Laboratory Medicine.
2) Research on diagnosis and treatment of
Our research on the pathophysiological elucidation and treatment of
hematological malignancies is especially concerned with leukemia, multiple
myeloma and malignant lymphoma. In this research, we have collaborated with the
Laboratory Medicine, Pathology and Radiology Department.
3) Research on etiological study and treatment
We have reported the etiological features of HIV/AIDS patients in the
local area, and new aspects of treatment concerning AIDS complications are
investigated as the core model hospital for AIDS in Okayama Prefecture.
Chairman of Internal Medicine
Takashi SUGIHARA, MD, PhD
Director of Blood Transfusion Department
Hideho WADA, MD, PhD
Yoshiko MATSUHASHI, MD, PhD
Toshinori KONDO, MD, PhD
Hirotoshi TOKUNAGA, MD, PhD
Fuminori SANO, MD, PhD
Asako TAKEUCHI, MD, PhD
Risa SHIMIZU, MD, PhD
Harunoshin YASUI, MD
Seiji MATSUMOTO, MD
Momoko YOKOI, MD
Keiichi UCHIDA, MD
Rui HYO, MD
Postgraduate medical student
Cancer professional education program designed by Department Director
Tadashi HIROSE, MD
Blood cell biochemistry program designed by Department Director SUGIHARA
Seiko YAMADA, MD
Affiliated Hospitals and Associate Staffs
Department of General Internal Medicine 4, Kawasaki Medical School
Hidekazu NAKANISHI, MD, PhD
Division of Hematology, Department of Medicine, Fukuyama City Hospital
Yoshimasa SUETSUGU, MD, PhD
Kiyohito HAYASHI, MD