川崎医科大学 検査診断学教室 Department of Laboratory Medicine (Laboratory Hematology) , Kawasaki Medical School
Matsuoka A, Tochigi A, Kishimoto M, Nakahara T, Kondo T, Tsujioka T, Tasaka T, Tohyama Y, Tohyama K: Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis. Leukemia, in press.
Tamura H, Dan K, Yokose N, Iwakiri R, Ohta M, Sakamaki H, Tohyama K, Kondo A, Hyodo H, Nakamura K, Yamashita T, Elisseeva OA, Oka Y, Oji Y, Sugiyama H, Ogata K：Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheralblood in patients with myelodysplastic syndromes. Leuk Res, in press.
Kubo Y, Kakazu N, Tasaka T, Oka D, Hirose T, Matsuhashi Y, Wada H, Tohyama K, Sugihara T: Acute lymphocytic leukemia(ALL) with t(8;14)(q11.2;q32) in an elderly patient. Leuk Res, in press.
Harada H, Watanabe M, Suzuki K, Yanagita S, Suzuki T, Yoshida Y,Kimura A, Tsudo M, Matsuda A, Tohyama K, Taniwaki M, Takeshita K, Takatoku M,Ozawa K: Lenalidomide is active in Japanese patients with symptomatic anemia in low- or intermediate-1 risk myelodysplastic syndromes (MDS) with a deletion 5q abnormality. Int J Hematol 90:353-360, 2009.
Kondo T, Tasaka T, Sano F, Matsuda K, Kubo Y, Matsuhashi Y, Nakanishi H, Sadahira Y, Wada H, Sugihara H, Tohyama K: Philadelphia chromosome-positive acute myeloid leukemia (Ph+AML) treated with imatinib mesylate (IM): a report with IM plasma concentration and bcr-abl transcripts. Leuk Res 33:e137-138, 2009.
Hazama R, Qu X, Yokoyama K, Tanaka C, Kinoshita E, He J, Takahashi S, Tohyama K, Yamamura H, Tohyama Y: ATP-induced osteoclast function; the formation of sealing-zone like structure and the secretion of lytic granules via microtubule-deacetylation under the control of Syk. Genes to Cells 14:871-884, 2009.
Mannouji K, Tasaka T, Akiyama T, Irei I, Sano F, Matsuhashi Y, Wada H, Tohyama K, Sugihara T, Sadahira Y: Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch. Pathol Internatl 59:261-264, 2009.
Nishikawa Y, Sato H, Oka T, Yoshino T, Takahashi K: Immunohistochemical discrimination of plasmacytoid dendritic cells from myeloid dendritic cells in human pathological tissues. J Clin Exp Hematop 49:23-31, 2009.
Sato Y, Kojima M, Takata K, Morito T, Asaoku H, Takeuchi T, Mizobuchi K, Fujihara M, Kuraoka K, Nakai T, Ichimura K, Tanaka T, Tamura M, Nishikawa Y, Yoshino T: Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman's disease. Mod Pathol 22:589-99, 2009.
通山 薫：骨髄異形成症候群．WHO分類第4版による白血病・リンパ系腫瘍の病態学 （押味和夫 監修、木崎昌弘・田丸淳一 編集）, ｐ87－102, 中外医学社, 2009.
Tasaka T, Tohyama K, Kishimoto M, Ohyashiki K, Mitani K, Hotta T, Kanamaru A, Okamoto S, Karasawa M, Kimura A, Tomonaga M, Uchiyama T, Ozawa K: Myelodysplastic syndrome (MDS) with chromosome 5 abnormalities : a nation-wide survey in Japan. Leukemia 22:1874-1881,2008.
Kondo T, Okuno N, Naruse H, Kishimoto M, Tasaka T, Tsujioka T, Matsuoka A, Sugihara T, Tohyama Y, Tohyama K: Validation of the revised 2008 WHO diagnostic criteria in 75 suspected cases of myeloproliferative neoplasm. Leuk Lymphoma 49:1784-1791, 2008.
Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A: High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood 112:3412-3424,2008.
Higa T, Tasaka T, Kubo Y, Nakagiri I, Sano F, Matsuhashi Y, Fukai Y, Wada H, Tohyama K, Sugihara T: Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intravenous linezolid in an allogeneic cord blood stem cell transplant recipient. Scand J Infect Dis, 40:990-992, 2008.
Tsujioka T, Tochigi A, Kishimoto M, Kondo T, Tasaka T, Wada H, Sugihara T, Tohyama K: DNA ploidy and cell cycle analysis in the bone marrow cells of the patients with megaloblastic anemia using a laser scanning cytometry. Cytometry B (Clin Cytometry) 74:104-109, 2008.
Wakimoto T, Tomisaka R, Nishikawa Y, Sato H, Yoshino T, Takahashi K: Identification and characterization of human thymic cortical dendritic macrophages that may act as professional scavengers of apoptotic thymocytes. Immunobiology 213:837-47, 2008.
大倉 貢、岩知道伸久、高橋佳子、秋山 隆、通山 薫、定平吉都：May-Gruenwald-Giemsa染色を施した骨髄塗抹保存標本を用いた免疫細胞学的染色法の試み. 日本検査血液学会雑誌 9:16-22，2008.（第9回日本検査血液学会学術賞受賞論文）
Noda C, He J, Takano T, Tanaka C, Kondo T, Tohyama K, Yamamura H, Tohyama Y: Induction of apoptosis by epigallocatechin-3-gallate in human lymphoblastoid B cells. Biochem Biophys Res Comm 362:951-957, 2007.
Ishikawa T, Tohyama K, Nakao S, et al: A prospective study of cyclosporine A treatment of patients with low-risk myelodysplastic syndrome: presence of CD55-CD59- blood cells predicts platelet response. Int J Hematol 86:150-157, 2007.
Yang J, Ikezoe T, Nishioka C, Tasaka T, et al：AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood 110:2034-40, 2007.
Nishioka C, Ikezoe T, Takeshita A, Yang J, Tasaka T, et al：ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244. Leukemia 21:1308-10, 2007.
Matsuhashi Y, Tasaka T, Kakazu N, et al：Establishment and characterization of the new splenic marginal zone lymphoma-derived cell line UCH1 carrying a complex rearrangement involving t(8;14) and chromosome 3. Leuk Lymphoma 48:767-73, 2007.
通山 薫：特別講演「骨髄異形成症候群、診断と治療の進歩」日本検査血液学会第8回学術集会、2007年7月. [日本検査血液学会雑誌 8：375-382，2007に掲載]
Shi Y, Tohyama Y, Kadono T, He J, Shahjahan Miah SM, Hazama R, Tanaka C, Tohyama K, Yamamura H: Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosis. Blood 107:4554-62, 2006.
Tamechika Y, Iwatani Y, Tohyama K, Ichihara K: Insufficient filling of vacuum tubes as a cause of microhemolysis and elevated serum lactate dehydrogenase levels. Use of a data-mining technique in evaluation of questionable laboratory test results. Clin Chem Lab Med 44:657-61, 2006.
Ikezoe T, Nishioka C, Tasaka T, et al: The antitumor effects of sunitinib(formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling. Mol Cancer Ther 10:2522-30, 2006.
Tsujioka T, Miura Y, Otsuki T, Nishimura Y, Hyodoh F, Wada H, Sugihara T: The mechanisms of vitamin K2-induced apoptosis of myeloma cells. Haematologica 91: 613-619, 2006.
Kurihara R, Tohyama Y, Matsusaka S, Naruse H, Kinoshita E, Tsujioka T, Katsumata Y, Yamamura H: Effects of peripheral cannabimoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils. J Biol Chem 281:12908-12918, 2006.
Tohyama K, Shiga S, Itose Y, Uchihashi K, et al: Improved Detection of Minimal Acute Myeloid Leukemia Cells by the Use of the Combined Parameters of XE-2100 Hematology Analyzer. Cytometry B (Clin Cytometry) 66:18-24, 2005.
He J, Tohyama Y, Yamamoto K, Kobayashi M, Shi Y, Takano T, Noda C, Tohyama K, Yamamura H: Lysosome is a primary organelle in B cell receptor-mediated apoptosis: an indispensable role of Syk in lysosomal function. Genes to Cells 10:23-35, 2005.
Matsusaka S, Tohyama Y, He J, Shi Y, Hazama R, Kadono T, Kurihara R, Tohyama K, Yamamura H: Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells. Biochem Biophys Res Comm 328:1163-1169, 2005.
通山 薫：教育講演「MDS―この難解な疾患へのアプローチ」 第67回日本血液学会総会＆第47回日本臨床血液学会総会・合同総会、2005年9月. [臨床血液 47:167-175, 2006に掲載]
通山 薫：生涯教育講演会「骨髄異形成症候群―その診断と治療戦略について」 日本内科学会生涯教育講演会Bセッション、2005年3月、6月、10月の3回講演. [日本内科学会雑誌 95:538-543, 2006に掲載]
Tasaka T, Matsuhashi Y, Uehara E, Tamura T, Kakazu N, et al： Secondary acute monocytic leukemia with a translocation t(8;16)(p11;p13): case report and review of the literature. Leuk Lymphoma 45:621-625, 2004.
Matsuhashi Y, Tasaka T, Uehara E, Fujimoto M, Fujita M, et al： Diffuse large B-cell lymphoma presenting with hypercalcemia and multiple osteolysis. Leuk Lymphoma 45:397-400, 2004.
通山 薫：骨髄異形成症候群. 新WHO分類による白血病・リンパ系腫瘍の病態学. （木崎、押味編）51-63、中外医学社, 2004.
Tohyama K, Shiga S, Fujimoto H, Hamaguchi Y, Ichiyama S: Automated analysis of differentiation-induced leukemic cells during all-trans retinoic acid therapy of acute promyelocytic leukemia. Archiv Pathol Lab Med 127:e4-e10, 2003.
Shimamoto T, Tohyama K, Okamoto T, Uchiyama T, et al: Cyclosporin A therapy for patients with myelodysplastic syndrome: multicenter pilot studies in Japan. Leukemia Res 27:783-788, 2003.
Nishihara T, Miura Y, Tohyama Y, Mizutani C, Hishita T, Ichiyama S, Uchiyama T, Tohyama K: Effects of Tyrosine Kinase Inhibitor, Imatinib Messylate on a Bcr-Abl-Positive Cell Line: Suppression of the Autonomous Cell Growth but No Effect on the Decreased Adhesive Property and Morphological Changes. Int J Hematol 78:233-240, 2003.
Matsuhashi Y, Tasaka T, Uehara E, et al: Increased expression of c-maf in pure red cell aplasia secondary to plasma cell dyscrasia. Leuk Lymphoma 44:523-524, 2003.
通山 薫：骨髄異形成症候群. ダイナミックメディシン（下条、斉藤編）、第3巻12章、95-97、西村書店、2003.
Ogata K, Nakamura K, Yokose N, Tamura H, Tachibana M, Taniguchi O, Iwakiri R, Hayashi T, Sakamaki H, Murai Y, Tohyama K, Tomoyasu S, Nonaka Y, Mori M, Dan K, Yoshida Y: Clinical significance of phenotypic features of blasts in patients with myelodysplastic syndrome. Blood 100:3887-3896, 2002.
Mizutani C, Tohyama Y, Miura Y, Hishita T, Nishihara T, Yamamura H, Ichiyama S, Uchiyama T, Tohyama K: Sustained activation of MEK1-ERK1/2 pathway in membrane skeleton occurs dependently on cell adhesion in megakaryocytic differentiation. Biochem Biophys Res Comm 297:664-671, 2002.
Itoh M, Yago K, Shimada H, Tohyama K: Reversible acceleration of disease progression following cyclosporin A treatment in a patient with myelodysplastic syndrome. Int J Hematol 75:302-304, 2002.
Shiga S, Fujimoto H, Mori Y, Sakata T, Hamaguchi Y, Wang F-S, Inomata Y, Tohyama K, Ichiyama S: Immature granulocyte count after liver transplantation. Clin Chem Lab Med 40:775-780, 2002.