HOME >>  Research - Introduction of Departments - Hematology


  • Takashi Sugihara, MD, PhD Professor of Medicine, Head, Division of Hematology
  • Hideho Wada, M.D., Ph.D. Professor
INDEX :  Main Areas and Themes of Research    Clinical Features
       Educational Features

Main Areas and Themes of Research

1) Research on red blood cells

Since the establishment of our division, we have carried out research on red blood cells as a main theme. Some staff members of our division who have proceeded to a doctor’s degree through research on this theme continue research on red blood cell membrane disorders.

2) Research on diagnosis and treatment of hematological malignancies.

Our research on the pathophysiological elucidation and treatment of hematological malignancies is especially concerned with leukemia, multiple myeloma and malignant lymphoma. In this research, we have collaborated with the Laboratory Medicine, Pathology and Radiology Department.

3) Research on etiological study and treatment of HIV/AIDS

We have reported the etiological features of HIV/AIDS patients in the local area, and new aspects of treatment concerning AIDS complications are investigated as the core model hospital for AIDS in Okayama Prefecture.

Clinical Features

1) Analysis of the mechanism in patients with hemolysis.

We have already conducted the analysis of more than 1,000 cases with hemolytic anemia of unknown mechanism, and provided the analytical results to many hospitals in Japan.

2) Pathophysiological clarification and treatment of autoimmune hematological disease.

Autoimmune hematological diseases are autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, aplastic anemia and low-grade myelodysplastic syndrome. We have applied immune therapy to these diseases.

3) Pathophysiological elucidation and treatment of hematological malignancies

We have provided individual treatments to patients with hematological malignancies such as leukemia, myeloma and malignant lymphoma. We collaborate not only with the Pathology and Radiology Department, but also with many other departments. We think a combined modality therapy is very important for patients with hematological malignancies.

4) Hematopoietic stem cell transplantation

We performed 146 cases of hematopoietic stem cell transplantation in the last six years, comprising 38 auto PBSCT, 82 CBT, 15 allo-BMT and 11 allo-PBSCT.

5) Clinical service as the core model hospital for AIDS

We provide clinical services for HIV/AIDS patients and education to medical doctors and paramedical staff who may have contact with HIV/AIDS patients as the core model hospital for AIDS in Okayama Prefecture.

Educational Features

1) Student instruction
i) Introduction to internal medicine as clinical medicine

It is important to create a good clinician before clinical training is started, and to acquire self-knowledge and a fundamental ability as a medical doctor to the highest degree.

ii) C1assified block lectures on hematology

The lectures are carried out during the first term of the third year. Hematological disorders may almost be divided into four groups: 1) Red cell disease, 2) Granulocyte disease, 3) Lymphocyte disease which causes swelling in the lymphoid tissue, and 4) Abnormal coagulation disorders. The lectures deal with these disease groups, while contrasting normal states with those that are abnormal.

iii) Clinical practice training in hematological disease

During the fifth year, students study clinical cases in small groups of six persons or less. Clinical physicians guide each group carefully.

iv) Summary of Hematology

During the sixth year, students receive hematology lectures to organize their knowledge and to approach disorders from the standpoint of symptoms.

2) Postgraduate education program

Our hospital has a training system in which residents (called junior residents) study in all clinical sections for two years. In this program, they are required to not only learn the basic rules for physicians, but also to gain the knowledge necessary to become a specialist in internal medicine who will become a fellow of the Japanese Society of Internal Medicine. As senior residents, they then undergo training to become a specialist in the hematological section to become a fellow of the Japanese Society of Hematology. After this training, they take the graduate course and study how to solve clinical problems from various points of view.