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Pediatrics

  • Kazunobu Ouchi, M.D., Ph.D. Professor, Chairman
  • Kihei Terada, M.D., Ph.D. Professor
  • Takashi Nakano, M.D., Ph.D. Professor

Emphasis and Outline for Education and Clinical Features

Pediatrics is the branch of general internal medicine for children. However, the biggest difference from internal medicine for adults is that children are always growing and developing from the neonate to the adult, and children complain about different symptoms than those of adults.

Pediatrics in our school is divided into 1) growth, development (physical, mental, physiological and psychological) and nutrition, 2) healthy raising; a) child care, check-up, hygiene, b) prevention against diseases and protection against accidents, c) social pediatrics (welfare and school hygiene), and 3) diseases of children, a) diagnosis (pathophysiology, symptomatology and physical examination), b) treatment (pharmacokinetics/dynamics, intravenous infusion, nursing, nutrition, and so on).

It is important to see numerous types of problems and diseases in neonates, infants, children and adolescents comprehensively as a member of a family and regional society. Diseases in children include many acute and chronic types, including diseases of the premature and neonates, congenital and genetic diseases, dysfunction of the organs, psychological problems and behavioral abnormalities.

Our goal for education is to train young doctors and medical students to become general pediatricians with a high subspecialty, such as neonatology, microbiology, neurology, immunology, hematology, oncology, cardiology, nephrology, gastroenterology, etc. Specialization is developing gradually even in pediatrics, so it is becoming hard to be simply a general pediatrician. We try to integrate these specialties in our school and other renowned institutes inside and outside of Japan through our refined curriculum.

Main Areas and Themes of Study

Our research is conducted in the postgraduate school, which mainly involves basic research, and also in the Kawasaki Medical School Hospital, which mainly encompasses clinical research. Our focus includes infection and immunity, allergy, hematology and oncology.

Research themes include:
  1. Mechanism of acute and persistent infection in Chlamydophila pneumoniae
  2. Pathophysiology on the association between Chlamydophila pneumoniae and asthma or athrosclerosis
  3. Surveillance and optimal treatment in children for Macrolide-resistant Mycoplasma pneumoniae
  4. Immunological investigations of patients with herpes zoster and chickenpox
  5. Comparison of secretory IgA antibody after natural infection and vaccination
  6. Identification of VZV DNA in patients with zoster sine herpete (Bell's palsy) and effects of antiviral drugs
  7. Research on vaccine preventable diseases mainly focused on epidemiological survey and disease burden, and leading the clinical trials for those vaccines.
  8. Research on new compounds and vaccines for influenza.
  9. Research on bone marrow transplantation and peripheral blood stem cell transplantation for malignancy

(1) Ogino K, Obase Y, Takahashi N, Shimizu H, Takigawa T, Wang DH, Ouchi K, Oka M:High serum arginase I levels in asthma: its correlation with high-sensitivity C-reactive protein. J Asthma : official journal of the Association for the Care of Asthma 48:1-7, 2011

(2) Nakano T:Japanese vaccinations and practices, with particular attention to polio and pertussis. Travel Med Infect Dis. in press,2011

(3) Uehara S, Sunakawa K, Eguchi H et al:Japanese Guidelines for the Management of Respiratory Infectious Diseases in Children 2007 with focus on pneumonia. Pediatr Int. Epub ahead of print, 2010

(4) Miyashita N, Oka M; Atypical Pathogen Study Group, Kawai Y, Yamaguchi T, Ouchi K: Macrolide-resistant Mycoplasma pneumoniae in adults with community-acquired pneumonia. Int J Antimicrob Agents. 36:384-5, 2010

(5) Miyashita N, Maruyama T, Kobayashi T, Kobayashi H, Taguchi O, Kawai Y, Yamaguchi T, Ouchi K, Oka M: Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age. J Infect Chemother. Epub ahead of print, 2010

(6) Onouchi Y, Ozaki K, Buns JC et al : Common variants in CASP3 confer susceptibility to Kawasaki disease. Hum Mol Genet. 19:2989-2906,2010

(7) Miyashita N, Kawai Y, Yamaguchi T, Ouchi K, Kobashi Y, Oka M: Evaluation of false-positive reaction with ELISA for the detection of Chlamydophila pneumoniae -specific IgM antibody in adults. Jpn J Infect Dis. 63:150-151,2010

(8) Namikawa Kyoko, Iida Tadayuki, Ouchi Kazunobu, Kimura Mikiko: Knowledge, attitudes, and practices of Japanese travelers on infectious disease risks and immunization uptake. J Travel Med 17:171-175, 2010

(9) Okada K, Komiya T, Yamamoto A, Takahashi M, Kamachi K, Nakano T, Nagai T, Okabe N, Kamiya H, Nakayama T:Safe and effective booster immunization using DTaP in teenagers. Vaccine 28:7626-7633,2010.

(10) Kamiya H, Nakano T, Inoue M, Kamiya H, Abd TT, Patel M, Orenstein WA, Parashar UD:A retrospective evaluation of hospitalizations for acute gastroenteritis at 2 sentinel hospitals in central Japan to estimate the health burden of rotavirus. J Infect Dis 200:S140-146,2009