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Hepatology and Pancreatology

  • Keisuke Hino, M.D., Ph.D., Professor
INDEX :  Main Areas and Themes of Research    Clinical Features
       Educational Features

Main Areas and Themes of Research

Main areas of research are pathogenesis and treatment of hepatobiliary and pancreatic disease.

Themes of research are as follows:

I . Molecular mechanisms of hepatocarcinogenesis, especially focusing on oxidative stress

II . Iron metabolic disorder in liver diseases

III . Mitochondrial disorder in liver diseases

IV . Nutritional and metabolic analysis of nonalcoholic steatohepatitis and liver cirrhosis

V . Development of diagnostic tools for biliary and pancreatic diseases using endoscopic procedures and molecular analysis

VI . Pathogenesis of autoimmune pancreatitis

Clinical Features

For liver diseases:

More than 70% of chronic liver diseases in Japan are associated with hepatitis C virus (HCV) or hepatitis B virus (HBV), while nonalcoholic fatty liver diseases (NAFLD) are also increasing. A proportion of these chronic liver diseases progress to liver cirrhosis and/or hepatocellular carcinoma (HCC). Therefore, we are concerned to treat these chronic liver diseases in terms of prevention of HCC development, even though we also actively treat acute liver diseases such viral hepatitis, liver abscess, and acute liver failure.

I . Chronic hepatitis B and C

Antiviral therapy such as nucleoside analogs and pegylated interferon has actively been performed for patients with chronic hepatitis B or C.

II . NALFD and liver cirrhosis

We treat patients with NAFLD and liver cirrhosis by evaluating their nutritional and energy metabolic condition using a body component analyzer and/or indirect calorimetry. These assessments and nutritional therapy are conducted by a nutritional supporting team comprising medical doctors and a dietitian.

HCV-associated liver cirrhosis is also treated with interferon in some cases.


Radiofrequency ablation therapy, percutaneous ethanol injection therapy, and/or transarterial chemoembolization are performed for the treatment of HCC.

For biliary and pancreatic diseases:

In comparison to HCC, the diagnosis of biliary and pancreatic malignancies at the early stage of progression remains difficult. We are successful in detecting these malignancies at an earlier stage through the use of endoscopic retrograde cholangio-pancreatography, endoscopic ultrasonography, fine-needle aspiration, and/or cytology of bile or pancreatic juice.

Educational Features

Our basic concept in education is to develop the minds of undergraduate and postgraduate students by focusing on the causes of the diseases and possible cures or solutions.