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Clinical Oncology

  • Yoshiyuki Yamaguchi, M.D., Ph.D. Professor

Main Areas and themes of Research

Cancer chemotherapy has advanced remarkably. The development of more effective new combinations in cancer chemotherapy requires clinical trial studies, in addition to basic research that provides the theoretical basis upon which to develop novel strategies. In the search for new anti-tumor drug combinations, we will demonstrate clinical studies with an emphasis on chemotherapy, angiogenic precursor cells, and angiogenesis inhibitors. Additionally, we are carrying out high priority research in the field of cancer therapy using activated autologous lymphocytes and cancer vaccines, in combination with investigations pertaining to regulation of the immune suppressive mechanism based on cancer pathophysiological conditions, and in combination with the use of new anti-tumor drugs. In the area of palliative care, clinical studies to assess the validity of new titration methods for introducing opioids and the evaluation of introducing molecular biological techniques for the prognosis of side effects and countermeasures are continuing.

1) Molecular clarification of cancer pathophysiology
  1. Analysis of local lymph nodes as well as whole body immune responses in pathological conditions of solid tumors and in cancerous chest-abdominal fluids
  2. Analysis of angiogenesis and host immune responses that accompany chemotherapy/radiotherapies against cancers
  3. Analysis of host immune response in palliative care
2) Research on new drug development
  1. Development of new combined chemotherapies
  2. Development of advanced cancer immunotherapies
  3. Development of new palliative care

Clinical Features

  1. Standard chemotherapy
  2. Second opinion system
  3. Palliative care
  4. Cancer immunotherapy (Cancer vaccines, Activated autologous lymphocyte Therapy)

Educational Features

1) Clinical Oncology Lectures

The Clinical Oncology department provides lectures as part of the Neoplasm section. Beginning with the Epidemiology of cancer, tumor-accompanied syndromes are then studied. In therapeutics, we will learn about anti-tumor drugs, clinical pharmacology, and standard chemotherapies and palliative care treatment corresponding to various types of tumors/cancers. Additionally, studies dealing with clinical trials and response evaluation, tumor statistics, and symptom theory that are necessary for new drug development will follow. The lecture content will cover the basics of clinical oncology to updated topics. In symptom theoretical studies, lectures are given through a tutorial method.

  1. Epidemiology of cancer
  2. Molecular understanding of pathophysiological conditions of cancer (e.g. Symptoms, Oncological emergency)
  3. Study of cancer treatment (e.g. Clinical pharmacology of Anti-tumor drugs, standard chemotherapy for various types of cancer)
  4. Advanced Medical Treatment
  5. Palliative medicine
2) Clinical practices
3) Internship practice after graduation