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General Internal Medicine 4

  • Nagio Takigawa, M.D., Ph.D., Professor

Main Areas and Themes of Research

Physicians try to develop diagnosis and treatment through an understanding of the biology of disease. Integration into basic research and clinical research, namely, translational research, helps clinicians to discover the cause of a disease and develop new treatments and methodologies for patient care. Thus, we have continued the translational research as follows:
Epidermal growth factor receptor (EGFR) signaling pathway in lung cancer

JAK2/STAT3 signals in erlotinib-resistance
Role of ERK reactivation mediated by SRC in gefitinib-resistance
Effect of everolimus and afatinib in EGFR-mutated transgenic mice
Role of hepatocyte growth factor in gefitinib-resistance
Efficacy of vandetanib on EGFR mutant cells with PTEN loss
Multiple molecular targeting effects by miR-7 in EGFR-driven cancer
Vascular endothelial growth factor receptor in EGFR-driven cancer
Inhibition of carcinogenesis by epigallocatechin-3-gallate
Oxidative damage-related mutagenesis in EGFR-mutated cancer
Detection of the EGFR mutation in exhaled breath condensate

DNA repair and PARP inhibition in lung cancer
Effect of whey protein in lung carcinogenesis
Cancer stem cells in small cell carcinoma
Mechanism in pemetrexed-resistant lung cancer
DNA methylation profile in malignant pleural mesothelioma
Carcinogenic mechanism in iron-induced rat mesothelioma

Clinical Features

Internal Medicine

Our department is one of four General Internal Medicine departments at Kawasaki Hospital. All the staff in the four departments are cooperatively engaged in both outpatient and inpatient care. We provide services with resident physicians and students. Methods to manage common diseases, communicate with patients, and refer to an appropriate specialist are used extensively. Management of respiratory disease is also undertaken as a subspecialty in general medicine because the professor is a fellow of the Japanese Respiratory Society and the Japan Society for Respiratory Endoscopy, in addition to a fellow of the Japanese Society of Internal Medicine.


Three medical oncologists hold board certificates from the Japanese Society of Medical Oncology and Japanese Cancer Therapy. Our expert Medical Oncology Team is focused on innovative research and excellent clinical care, with a strong commitment to the community through health screenings and educational programs. We specialize in advanced solid tumors including lung cancer, breast cancer, gastrointestinal cancers, genitourinary cancers, head and neck cancers, ovarian cancers, primary unknown cancers, pancreatic endocrine tumors, sarcomas, mesothelioma, germ cell tumors, and palliative medicine. Patients with a suspected or confirmed diagnosis of cancer have their diseases discussed at a team meeting, where the diagnostic or treatment plans are agreed. The non-surgical clinical practices and trials such as chemotherapy, molecular targeting agents, pharmacokinetics/pharmacodynamics, and supportive care utilize the latest innovations. We also engage in communication, cooperation and translational research concerning prevention, diagnosis and treatment of cancer. Finally, we contribute collectively to the advancement of science and well-being of people. We provide weekly academic conferences and/or lectures in the hospital. We present our research results at conferences and in peer-reviewed publications. Our team is always discussing recent knowledge and challenging new services in order to improve patient prognosis and QOL.