川崎医科大学・生理学2教室 

業績



Okabe N, Himi N, Nakamura-Maruyama E, Hayashi N, Sakamoto I, Narita K, Hasegawa T, Miyamoto O. Constraint-induced movement therapy improves efficacy of task-specific training after severe cortical stroke depending on the ipsilesional corticospinal projections. Exp Neurol.305, 108-120, 2018


Okabe N, Himi N, Nakamura-Maruyama E, Hayashi N, Narita K, Miyamoto O. Rehabilitative skilled forelimb training enhances remodeling in the corticospinal pathway but not the brainstem-spinal pathways after photothrombotic stroke in the primary motor cortex. PLoS One.12(11), e0187413, 2017


Okabe N, Narita K, Miyamoto O. Axonal remodeling in the corticospinal tract after stroke: how does rehabilitative training modulate it? Neural Regen Res.12(2), 185-192, 2017


Shiromoto T, Okabe N, Lu F, Maruyama-Nakamura E,Himi N, Narita K, Yagita Y, Kimura K, Miyamoto O. The role of endogenous neurogenesis in functional recovery and motor map reorganization induced by rehabilitative therapy after stroke in rats. J Stroke Cerebrovasc Dis.26(2), 260-72, 2017


Okabe N, Shiromoto T,Himi N,Lu F, Maruyama-Nakamura E, Narita K, Iwachidou N, Yagita Y, Miyamoto O. Neural network remodeling underlying motor map reorganization induced by rehabilitative training after ischemic stroke. Neuroscience 339, 338-62, 2016


Himi N, Takahashi H, Okabe N, Nakamura E, Shiromoto T, Narita K, Koga T, Miyamoto O. Exercise in the early stage after stroke enhances hippocampal brain-derived neurotrophic factor expression and memory function recovery. J Stroke Cerebrovasc Dis. 25(12), 2987-94, 2016


Lu F, Nakamura T, Okabe N, Himi N, Nakamura-Maruyama E, Shiromoto T, Narita K, Tsukamoto I, Xi G, Keep RF, Miyamoto O. COA-Cl, a novel synthesized nucleoside analog, exerts neuroprotective effects in the acute phase of intracerebral hemorrhage.  J Stroke Cerebrovasc Dis. 25(11), 2637-43, 2016


Nakano S, Yokoyama Y, Aoyagi S, Himi N, Fletcher JS, Lockyer NP, Henderson A, Vickerman JC. :Evaluation of biomolecular distributions in rat brain tissues by means of ToF-SIMS using a continuous beam of Ar clusters. Biointerphases. 11(2), 02A307, 2016


Nakamura-Maruyama E, Miyamoto O, Okabe N, Himi N, Feng L, Narita K, Keep RF, Yamamoto T, Nakamura T : Ryanodine receptors contribute to the induction of ischemic tolerance. Brain Res Bull. 122, 45-53, 2016


Lu F, Nakamura T, Toyoshima T, Liu Y, Shinomiya A, Hirooka K, Okabe N, Miyamoto O, Tamiya T, Keep RF, Itano T : Neuroprotection of granulocyte colony-stimulating factor during the acute phase of transient forebrain ischemia in gerbils. Brain Res 1548, 49-55, 2014


Tomita M, Katsuyama H, Watanabe Y, Okuyama T, Fushimi S, Ishikawa T, Nata M, Miyamoto O : Does methamphetamine affect bone metabolism?. Toxicology 319, 63-8, 2014


Okabe N, Nakamura E, Himi N, Narita K, Tsukamoto I, Maruyama T, Sakakibara N, Nakamura T, Itano T, Miyamoto O : Delayed administration of the nucleic acid analog 2Cl-C.OXT-A attenuatesbrain damage and enhances functional recovery after ischemic stroke. Brain Res 1506, 115-31, 2013


Du YH, Hirooka K, Miyamoto O, Bao YQ, Zhang B, An JB, Ma JX : Retinoic acid suppresses the adhesion and migration of human retinal pigment epithelial cells. Exp Eye Res 109, 22-30, 2013


Himi N, Hamaguchi A, Hashimoto K, Koga T, Narita K, Miyamoto O : Calcium influx through the TRPV1 channel of endothelial cells (ECs)correlates with a stronger adhesion between monocytes and ECs. Adv Med Sci57(2), 224-9, 2013


Lu F, Nakamura T, Toyoshima T, Liu Y, Hirooka K, Kawai N, Okabe N, Shiraga F, Tamiya T, Miyamoto O, Keep RF, Itano T : Edaravone, a free radical scavenger, attenuates behavioral deficitsfollowing transient forebrain ischemia by inhibiting oxidative damage in gerbils. Neurosci Lett 506(1), 28-32, 2012


Takahashi H, Himi N, Kuniyasu K, Koga T : Changes in the lactate threshold during treadmill exercise after microsphere-induced infarction in rats. J Stroke Cerebrovasc Dis 21(8), 647-51, 2012


Okabe N, Nakamura T, Toyoshima T, Miyamoto O, Lu F, Itano T : Eicosapentaenoic Acid prevents memory impairment after ischemia by inhibiting inflammatory response and oxidative damage. J Stroke Cerebrovasc Dis 20(3), 188-95, 2011


Nakamura T, Tanaka S, Hirooka K, Toyoshima T, Kawai N, Tamiya T, Shiraga F, Tokuda M, Keep R, Itano T, Miyamoto O : Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat. Neurosci Lett 487(1), 103-6, 2011


Nakamura T, Kuroda Y, Hosomi N, Okabe N, Kawai N, Tamiya T, Xi G, Keep RF, Itano T : Serine protease inhibitor attenuates intracerebral hemorrhage-induced brain injury and edema formation in rat. Acta Neurochir Suppl 106(1), 307-10, 2010


Tanaka S, Nakamura T, SumitaniK, TakahashiF, Konishi R, Itano T, Miyamoto O : Stage-and region-specificcyclooxygenase expression and effects of a selective COX-1 inhibitor in themouse amygdala kindling model. Neurosci Res 65, 79-87, 2009



Du Y, Hirooka K, Miyamoto O,Itano T, Tokuda M, Shiraga F : Both amacrine and bipolar cells releaseglutamate in the rat retina after ischemia/ reperfusion insult in vitro. Curr Eye Res 33, 782-8, 2008



Nakamura T, Miyamoto O,Toyoshima T, Hirooka K, Kawai N, Shiraga F, Tamiya T, Xi G, Keep RF, Itano T :3CB2, a marker of radial glia, expression after experimental intracerebralhemorrhage : role of thrombin. Brain Res 1226, 156-62, 2008



Nakamura T, Kuroda Y, YamashitaS, Zhang X, Miyamoto O, Tamiya T, Nagao S, Guohua X, Keep F, Itano T :Edaravone attenuates brain edema and neurological deficits in a rat model ofacute intracerebral hemorrhage. Stroke 39, 463-9, 2008



Kurozumi C, Yamagata R, Himi N, Koga T : Emetic stimulation inhibits the swallowing reflex in decerebrate rats.Auton Neurosci 140, 24-9, 2008



Hachisuka J, Soga-Sakakibara S,Kubota M, Narita K, Kuba K : Enhancement of Ca2+-induced Ca2+ release by cyclicADP-ribose in frog motor nerve terminals. Neuroscience 146, 123-34, 2007



Okada M, Miyamoto O, Shibuya S,Zhang X, Yamamoto T, Itano T : Expression and role of type I collagen in a ratspinal cord contusion injury model. Neurosci Res 58, 371-7, 2007



Hirooka K, Miyamoto O, JinmingP, Du Y, Itano T, Baba T, Tokuda M, Shiraga F : Neuroprotective effects ofD-allose against retinal ischemiareperfusion injury. InvestOphthalmol Vis Sci 47, 1653-7, 2006



Kubota M, Narita K, Murayama T,Suzuki S, Soga S, Usukura J, Ogawa Y, Kuba K : Type-3 ryanodine receptorinvolved in Ca2+-induced Ca2+ release and transmitter exocytosis at frog motornerve terminals. Cell Calcium 38, 557-67, 2005



Wu D, Miyamoto O, Shibuya S,Mori S, Norimatsu H, Janjua NA, Itano T : Co-expression of radial glial markerin macrophages/microglia in rat spinal cord contusion injury model. Brain Res1051, 183-8, 2005